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Treating malaria through Psoriasis drugs

Date: 21 September 2019 Tags: Miscellaneous

Issue

Drug used for treating skin disease Psoriasis may now be used to effectively treat malaria, suggests recent study.

 

Background

Malaria is caused by the parasite Plasmodium falciparum, which is transmitted to humans from the bite of an infected Anopheles mosquito.

 

Details

  • Researchers modified a class of molecules called pantothenamides to increase their stability in humans.

  • The new compounds stop the malaria parasite from replicating in infected humans and from being transmitted to mosquitoes and are effective against malaria parasites resistant to currently available drugs.

  • Pantothenamides are extremely potent against the malaria parasite, but they become unstable within biological fluids because an enzyme clips them apart before they can act.

  • Changing a chemical bond in a pantothenamide molecule prevents this clipping, making it viable for use as a new antimalarial drug.

  • The team found that the modified pantothenamide molecules not only interferes with the development of the malaria parasite during its asexual growth phase in the blood but also prevent transmission of the sexual form of the parasite from human blood to mosquitoes.

  • The major advantage of this drug is that there's no resistance to the drug as yet, and it is effective against many forms of malaria.