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Current Affairs

Protein-based vaccine

Date: 14 August 2021 Tags: Miscellaneous

Issue

Nanoparticles that mimic SARS-CoV-2 were used by researchers to immunize mice against the viral disease.

 

Details

  • Researchers made use of receptor binding domain (RBD) antigen to generate an anti-body response in the mice.

  • Nanoparticles were made similar to SARS CoV-2 and were implanted with many RBDs. They were then injected into mice.

  • Along with this decorated nanoparticles, researchers inserted separate nanoparticles containing adjuvant in form of separate doses.

  • Another group of mice were immunized with the help of RBD encapsulated polymersomes to compare with the nanoparticles.

  • High levels of RBD specific antibodies were generated in the bodies of the mice but neutralizing antibodies were produced in mice given surface decorated nanoparticles.

 

RBD

  • Receptor Binding Domain (RBD) can be considered as a critical part of viral protein that makes contact with the cell and allows entry of viral DNA inside.

  • The RBD is located near the spike protein and is the primary target of drugs trying to prevent the virus from infecting healthy cells.

 

Nanoparticles

  • Nanoparticles are types of matter that ranges between the size of 1 to 100 nanometers. These particles have unique physical and chemical characteristics that are not visible to naked eye.

  • Due to their precision and non-corrosive nature, nanoparticles are particularly used in medical science, food packaging and electronics technology.