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Current Affairs

Oral diabetes medicine

Date: 18 November 2021 Tags: Biotechnology

Issue

 Oral medication to treat diabetes has been developed by researchers. The medicines will controls insulin levels and keep inflammatory effects down.

 

Background

The medicine has been developed by Tarek Fahmy, associate professor of biomedical engineering at Yale University.

 

Details

  • The biggest advantage of the medicine is that it can be taken orally, and is easier for patients to stay compliant with his or her treatment. 

  • Other benefits include restoration of pancreatic function, controlling immediate blood glucose levels and re-establish normal immunity in the pancreatic environment.

 

Composition

It is made up of a nanocarrier composed of materials that is made by our own bodies. In short term, the normal metabolism is restored.

 

Challenges

  • Developing oral diabetic medicine is difficult because the drug breaks down in the patient’s gastrointestinal system. 

  • The new drug is made up of nanoparticle that protects the insulin while carrying it to the site of the pancreas.

  • A polymerised ursodeoxycholic acid is used as a nanoparticle. It is used as a drug for dissolving gallstones and liver stones.

  • The nanoparticle was modified by the research team to increase its ability to bind with receptors critical to metabolism.

 

The tests

Tests on mice showed that nanoparticles reversed inflammation, restored metabolic functions, and extended their survival.

 

Diabetes

Diabetes is a disease in which the pancreas does not produce enough insulin to keep blood glucose level under limit.