New treatment that targets cell damaged rather than virusDate: 25 June 2021 Tags: Miscellaneous
A new treatment model that focuses on fixing damage to cells rather than fighting the SARS CoV-2 virus has proved successful.
At present they have been used against animal models. If they are found safe for humans, the symptoms of Covid-19 can be made milder.
The current treatment methods have generally focused on the virus itself, with drugs targeting the viral structure. The new method has involved cellular response.
Scientists infected cells with SARS CoV-2 virus to determine the effects. They found that infected cells activated a signalling pathway called ‘unfolded protein response’ (UPR).
By preventing the ‘unfolded protein response’ (UPR), it was found that cell function was restored and viral replication reduced.
Reversing the cellular pathway using drugs stopped viral replication process inside cells drastically and infection did not spread to other cells.
The currently used drugs such as Remdesivir prevent replication of virus itself. But after some time the virus obtains resistance for these drugs.
Since the new treatment method targets the cellular response to viral attack, it will remain effective even if virus mutates.