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Current Affairs

New treatment that targets cell damaged rather than virus

Date: 25 June 2021 Tags: Miscellaneous

Issue

A new treatment model that focuses on fixing damage to cells rather than fighting the SARS CoV-2 virus has proved successful.

 

Background

At present they have been used against animal models. If they are found safe for humans, the symptoms of Covid-19 can be made milder.

 

Details

  • The current treatment methods have generally focused on the virus itself, with drugs targeting the viral structure. The new method has involved cellular response.

  • Scientists infected cells with SARS CoV-2 virus to determine the effects. They found that infected cells activated a signalling pathway called ‘unfolded protein response’ (UPR).

  • By preventing the ‘unfolded protein response’ (UPR), it was found that cell function was restored and viral replication reduced.

  • Reversing the cellular pathway using drugs stopped viral replication process inside cells drastically and infection did not spread to other cells.

  • The currently used drugs such as Remdesivir prevent replication of virus itself. But after some time the virus obtains resistance for these drugs.

  • Since the new treatment method targets the cellular response to viral attack, it will remain effective even if virus mutates.