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Tags Current Affairs

Antibodies protecting against the virus

Date: 07 May 2021 Tags: Miscellaneous

Issue

Researchers have come up with a detailed mechanism to explain how antibodies work to neutralise vaccine.

 

Background

When an individual is infected, the body produces antibodies to target the SARS-CoV-2 virus that causes Covid-19.

 

Details

  • Previous studies were focused on an important part of Coronavirus spike protein known as receptor-binding domain (RBD).

  • The receptor binding domain is the part of spike that attaches to healthy human cell and helps virus to infect them.

  • Researchers who studied blood serum of recovered SARS CoV-2 patients found that majority of the antibodies present in the serum targeted the viral spike protein outside the RBD.

  • The immune stem does not only focus on RBD but the entire spike. It covers both the arc and the stalk to neutralise the virus.

  • Majority of these non-RBD antibodies targeted a region known as N-terminal domain (NTD), which is similar to an umbrella canopy of the virus.

  • The NTD is a part of the viral spike that mutates often. This is the reason why virus variants are effective at avoiding our immune system.

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