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Tags Current Affairs

MMR vaccine

Date: 30 June 2020 Tags: Biotechnology

Issue

A new paper suggests that live attenuated vaccines such as MMR (measles, mumps and rubella) may prevent severe lung inflammation and sepsis associated with Covid-19 infection.

 

Background

A live attenuated vaccine is derived from a disease-causing pathogen, which has been weakened in the laboratory so that it does not cause severe illness when a person is vaccinated with it.

 

Details

  • The new research paper refers to growing evidence that live attenuated vaccines can activate certain immune cells to train leukocytes (the white blood cells of the immune system) to mount a more effective defence against unrelated infections.

  • The researchers used a live attenuated fungal strain and demonstrated, in the lab, that vaccination with it trained innate protection against sepsis (blood poisoning) caused by a combination of disease-causing fungi and bacteria.

  • The protection is produced by cells called MDSCs. They stressed that this live attenuated MMR vaccine concept is not suggested to be directed against Covid-19, but instead an immune preventive measure against the severe inflammatory symptoms of Covid-19.

  • The use of childhood live attenuated vaccines such as MMR given to adults to induce bystander cells that can dampen or reduce severe complications associated with Covd-19 infection is a low risk – high reward preventive measure during a critical period of the pandemic.

  • These bystander cells are long-lived but not life-long. Anyone who had an MMR vaccination as a child, while likely to still have immune antibodies directed against measles, mumps, or rubella, will not likely still have the immune cells directed against sepsis.

  • Scientists suggested that adults working in high-risk settings, who are not immune-compromised, pregnant, or allergic to vaccinations, get an MMR vaccine.

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