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Hypoxia adaptable Himalayan Wolves

Date: 24 February 2020 Tags: Biodiversity


Himalayan wolves, also called as Tibetan wolves, which live at more than 4,000 metres altitudes are genetically distinct from grey wolves, according to a study.



The study based on mitochondrial DNA supports an early divergence for the Himalayan wolves, making them the sister taxon to the grey wolves. The nuclear genome markers analysed also suggests differences between Himalayan wolves and grey wolves.



  • Living at such high altitudes, these wolves have genetically adapted themselves to live in low oxygen (hypoxic) conditions. While effective oxygen availability at sea level is nearly 22%, at 4,000 metres altitude, the effective oxygen availability is nearly half, 12.7%.

  • The researchers collected 280 wolf faeces from across the Tibetan Plateau of China, Kyrgyzstan and Tajikistan and studied the mitochondrial DNA. A subset of 110 samples was genotyped too. The genetic analysis revealed a clear divergence of Himalayan wolves and marked them as separate breed.

  • Unlike the grey wolves that inhabit the lower elevations the Himalayan wolves showed clear hypoxia adaptation. The admixed wolves had a mixture of genes belonging to Himalayan wolves and grey wolves but always carried the Himalayan wolf hypoxia adaptation.

  • The specialised genes for hypoxia adaptation allowed the animals to overcome the lack of oxygen at such high altitudes.

  • Such adaptations are seen in dogs and humans to mitigate the deleterious effects of free radicals that are produced in response to low oxygen availability.

  • While the precise genetic mechanism that facilitates humans to live in hypoxic conditions remain poorly understood, interbreeding of wolves and dogs is how the dogs might have acquired high-altitude adaptation.

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