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<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Adalimumab, sold by AbbVie under the brand name Humira, is a type of anti-inflammatory known as an anti-tumour necrosis factor (anti-TNF) drug.</span></span></p>
<p style="margin-right:0cm"> </p>
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<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Humira is used to treat a range of conditions including rheumatoid arthritis, Crohn's disease, ulcerative colitis and psoriasis.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Research has identified some treatments for hospitalised COVID-19 patients, including Gilead's remdesivir as well as the generic steroid drug dexamethasone.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
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<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
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<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
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<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
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'month' => '06',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 4 => object(Cake\ORM\Entity) {
'month' => '05',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 5 => object(Cake\ORM\Entity) {
'month' => '04',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 6 => object(Cake\ORM\Entity) {
'month' => '03',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 7 => object(Cake\ORM\Entity) {
'month' => '02',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 8 => object(Cake\ORM\Entity) {
'month' => '01',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 9 => object(Cake\ORM\Entity) {
'month' => '12',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 10 => object(Cake\ORM\Entity) {
'month' => '11',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 11 => object(Cake\ORM\Entity) {
'month' => '10',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 12 => object(Cake\ORM\Entity) {
'month' => '09',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 13 => object(Cake\ORM\Entity) {
'month' => '08',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 14 => object(Cake\ORM\Entity) {
'month' => '07',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 15 => object(Cake\ORM\Entity) {
'month' => '06',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 16 => object(Cake\ORM\Entity) {
'month' => '05',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 17 => object(Cake\ORM\Entity) {
'month' => '04',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 18 => object(Cake\ORM\Entity) {
'month' => '03',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 19 => object(Cake\ORM\Entity) {
'month' => '02',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
}
]
$days = [
'2021-09-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {}
],
'2021-08-02' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-07-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {}
],
'2021-06-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-05-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-04-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-03-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {}
],
'2021-02-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {}
],
'2021-01-06' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {}
],
'2020-12-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {},
(int) 28 => object(Cake\ORM\Entity) {},
(int) 29 => object(Cake\ORM\Entity) {}
],
'2020-11-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {},
(int) 28 => object(Cake\ORM\Entity) {}
],
'2020-10-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
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<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
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'[original]' => [[maximum depth reached]],
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'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
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},
(int) 14 => object(Cake\ORM\Entity) {
'month' => '07',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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[maximum depth reached]
],
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'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 15 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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],
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'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 16 => object(Cake\ORM\Entity) {
'month' => '05',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
[maximum depth reached]
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'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 17 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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[maximum depth reached]
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'[original]' => [[maximum depth reached]],
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'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 18 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 19 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[repository]' => 'currentaffairs'
}
]
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'2021-03-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
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(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {}
],
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],
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],
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]
]
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],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'sitebanners'
},
(int) 1 => object(Cake\ORM\Entity) {
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'bannername' => 'http://www.mediafire.com/convkey/0552/k9b1o467l8edtbc6g.jpg',
'bannerlink' => 'https://studyiq.com/courses/state-exams',
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],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'sitebanners'
},
(int) 2 => object(Cake\ORM\Entity) {
'id' => (int) 63,
'bannername' => 'http://www.mediafire.com/convkey/154a/6y1qvv7v118759h6g.jpg',
'bannerlink' => 'https://studyiq.com/course-details/upsc-ias-pre-mains',
'isright' => (int) 0,
'status' => (int) 1,
'[new]' => false,
'[accessible]' => [
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'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'sitebanners'
},
(int) 3 => object(Cake\ORM\Entity) {
'id' => (int) 64,
'bannername' => 'http://www.mediafire.com/convkey/563c/o65x6jso51flz886g.jpg',
'bannerlink' => 'https://studyiq.com/courses/upsc/optional-subjects',
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'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'sitebanners'
},
(int) 4 => object(Cake\ORM\Entity) {
'id' => (int) 70,
'bannername' => 'http://www.mediafire.com/convkey/23f5/ymfxsytttaix1ls6g.jpg',
'bannerlink' => 'https://www.studyiq.com/mock-test-series-ssc-bank-upsc-clat-kvs-rbi-dsssb-aao/upsc-ias-prelims-test-series-2021',
'isright' => (int) 0,
'status' => (int) 1,
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'[accessible]' => [
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'[dirty]' => [[maximum depth reached]],
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'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'sitebanners'
}
]
$params = []
$b = [
'name' => 'Current Affairs',
'link' => 'https://currentaffairs.studyiq.com/daily'
]
$cabymonth = object(Cake\ORM\Entity) {
'month' => '06',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
'*' => true
],
'[dirty]' => [],
'[original]' => [],
'[virtual]' => [],
'[errors]' => [],
'[invalid]' => [],
'[repository]' => 'currentaffairs'
}
$count = (int) 28
$scount = (int) 5
$currentaffair = object(Cake\ORM\Entity) {
'id' => (int) 5858,
'category_id' => (int) 10,
'title' => 'Anti-inflammatory drug as Covid treatment',
'description' => '<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Issue</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Adalimumab, sold by AbbVie under the brand name Humira, is a type of anti-inflammatory known as an anti-tumour necrosis factor (anti-TNF) drug.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Details</strong></span></span></p>
<ul>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Humira is used to treat a range of conditions including rheumatoid arthritis, Crohn's disease, ulcerative colitis and psoriasis.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Research has identified some treatments for hospitalised COVID-19 patients, including Gilead's remdesivir as well as the generic steroid drug dexamethasone.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
</li>
<li>
<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
</li>
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'title' => 'Anti-inflammatory drug as Covid treatment',
'description' => '<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Issue</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Adalimumab, sold by AbbVie under the brand name Humira, is a type of anti-inflammatory known as an anti-tumour necrosis factor (anti-TNF) drug.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Details</strong></span></span></p>
<ul>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Humira is used to treat a range of conditions including rheumatoid arthritis, Crohn's disease, ulcerative colitis and psoriasis.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Research has identified some treatments for hospitalised COVID-19 patients, including Gilead's remdesivir as well as the generic steroid drug dexamethasone.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
</li>
<li>
<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
</li>
</ul>
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April-2020 Current Affairs
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<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Adalimumab, sold by AbbVie under the brand name Humira, is a type of anti-inflammatory known as an anti-tumour necrosis factor (anti-TNF) drug.</span></span></p>
<p style="margin-right:0cm"> </p>
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<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Humira is used to treat a range of conditions including rheumatoid arthritis, Crohn's disease, ulcerative colitis and psoriasis.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Research has identified some treatments for hospitalised COVID-19 patients, including Gilead's remdesivir as well as the generic steroid drug dexamethasone.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
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<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
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'[invalid]' => [[maximum depth reached]],
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'[original]' => [[maximum depth reached]],
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'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 11 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
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'created_date' => object(Cake\I18n\FrozenDate) {},
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'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
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'[invalid]' => [[maximum depth reached]],
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
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],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 14 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 15 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 16 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 17 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 18 => object(Cake\ORM\Entity) {
'month' => '03',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 19 => object(Cake\ORM\Entity) {
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'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
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'[accessible]' => [
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'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
}
]
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(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
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(int) 14 => object(Cake\ORM\Entity) {},
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(int) 16 => object(Cake\ORM\Entity) {}
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(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
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(int) 25 => object(Cake\ORM\Entity) {}
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'2021-01-06' => [
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<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
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<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
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<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
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February-2020 Current Affairs
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'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 4 => object(Cake\ORM\Entity) {
'month' => '05',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 5 => object(Cake\ORM\Entity) {
'month' => '04',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 6 => object(Cake\ORM\Entity) {
'month' => '03',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 7 => object(Cake\ORM\Entity) {
'month' => '02',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 8 => object(Cake\ORM\Entity) {
'month' => '01',
'year' => '2021',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 9 => object(Cake\ORM\Entity) {
'month' => '12',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 10 => object(Cake\ORM\Entity) {
'month' => '11',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 11 => object(Cake\ORM\Entity) {
'month' => '10',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 12 => object(Cake\ORM\Entity) {
'month' => '09',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 13 => object(Cake\ORM\Entity) {
'month' => '08',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 14 => object(Cake\ORM\Entity) {
'month' => '07',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 15 => object(Cake\ORM\Entity) {
'month' => '06',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 16 => object(Cake\ORM\Entity) {
'month' => '05',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 17 => object(Cake\ORM\Entity) {
'month' => '04',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 18 => object(Cake\ORM\Entity) {
'month' => '03',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
},
(int) 19 => object(Cake\ORM\Entity) {
'month' => '02',
'year' => '2020',
'created_date' => object(Cake\I18n\FrozenDate) {},
'[new]' => false,
'[accessible]' => [
[maximum depth reached]
],
'[dirty]' => [[maximum depth reached]],
'[original]' => [[maximum depth reached]],
'[virtual]' => [[maximum depth reached]],
'[errors]' => [[maximum depth reached]],
'[invalid]' => [[maximum depth reached]],
'[repository]' => 'currentaffairs'
}
]
$days = [
'2021-09-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
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(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {}
],
'2021-08-02' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
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(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
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(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-07-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {}
],
'2021-06-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-05-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-04-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {}
],
'2021-03-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {}
],
'2021-02-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {}
],
'2021-01-06' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {}
],
'2020-12-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {},
(int) 28 => object(Cake\ORM\Entity) {},
(int) 29 => object(Cake\ORM\Entity) {}
],
'2020-11-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {},
(int) 28 => object(Cake\ORM\Entity) {}
],
'2020-10-01' => [
(int) 0 => object(Cake\ORM\Entity) {},
(int) 1 => object(Cake\ORM\Entity) {},
(int) 2 => object(Cake\ORM\Entity) {},
(int) 3 => object(Cake\ORM\Entity) {},
(int) 4 => object(Cake\ORM\Entity) {},
(int) 5 => object(Cake\ORM\Entity) {},
(int) 6 => object(Cake\ORM\Entity) {},
(int) 7 => object(Cake\ORM\Entity) {},
(int) 8 => object(Cake\ORM\Entity) {},
(int) 9 => object(Cake\ORM\Entity) {},
(int) 10 => object(Cake\ORM\Entity) {},
(int) 11 => object(Cake\ORM\Entity) {},
(int) 12 => object(Cake\ORM\Entity) {},
(int) 13 => object(Cake\ORM\Entity) {},
(int) 14 => object(Cake\ORM\Entity) {},
(int) 15 => object(Cake\ORM\Entity) {},
(int) 16 => object(Cake\ORM\Entity) {},
(int) 17 => object(Cake\ORM\Entity) {},
(int) 18 => object(Cake\ORM\Entity) {},
(int) 19 => object(Cake\ORM\Entity) {},
(int) 20 => object(Cake\ORM\Entity) {},
(int) 21 => object(Cake\ORM\Entity) {},
(int) 22 => object(Cake\ORM\Entity) {},
(int) 23 => object(Cake\ORM\Entity) {},
(int) 24 => object(Cake\ORM\Entity) {},
(int) 25 => object(Cake\ORM\Entity) {},
(int) 26 => object(Cake\ORM\Entity) {},
(int) 27 => object(Cake\ORM\Entity) {}
]
]
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'title' => 'Anti-inflammatory drug as Covid treatment',
'description' => '<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Issue</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Oxford University would study whether the world's best-selling prescription medicine, adalimumab, was an effective treatment for COVID-19 patients.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background</strong></span></span></p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Adalimumab, sold by AbbVie under the brand name Humira, is a type of anti-inflammatory known as an anti-tumour necrosis factor (anti-TNF) drug.</span></span></p>
<p style="margin-right:0cm"> </p>
<p style="margin-right:0cm"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Details</strong></span></span></p>
<ul>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Recent studies have shown that COVID-19 patients already taking anti-TNF drugs for inflammatory bowel disease and inflammatory arthritis are less likely to be admitted to hospital.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Humira is used to treat a range of conditions including rheumatoid arthritis, Crohn's disease, ulcerative colitis and psoriasis.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">The availability of biosimilar versions of the medicine, used for over two decades as an anti-flammatory, would make it affordable and accessible if the trial is successful.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Research has identified some treatments for hospitalised COVID-19 patients, including Gilead's remdesivir as well as the generic steroid drug dexamethasone.</span></span></p>
</li>
<li>
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Severe infections are believed to be triggered by an over-reaction of the immune system, known as a cytokine storm, and drugs that suppress certain elements of the immune system can play a role in arresting a rapid escalation of symptoms.</span></span></p>
</li>
<li>
<p><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">But there are not yet effective therapies for people who are not admitted to hospital. Care homes were particularly hard hit by the first wave of COVID-19 in the UK and other countries.</span></span></p>
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Cake\View\View::_render() - CORE/src/View/View.php, line 1157
Cake\View\View::render() - CORE/src/View/View.php, line 765
Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 623
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 125
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 93
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Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
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Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 81
